Conventional systemic Disease Modifying Antirheumatic drugs (csDMARDS) are viewed as disease-modifying drugs. They include Methotrexate, Sulfasalazine, Hydroxychloroquine and Azathioprine. Sulfasalazine and Hydroxychloroquine have limited effect on the immune system. If used for maintenance treatment, Methotrexate and Azathioprine are usually given at lower doses which do not cause a significant degree of immunosuppression.
If the donor is taking higher dose Methotrexate or Azathioprine, they should not be accepted. If there is uncertainty about the dose refer to the DCSO for assessment. Further information on these drugs and immunosuppression can be found in ‘The Green Book: Immunisation against Infectious Disease’ (available at www.gov.uk).
Nonsteroidal anti-inflammatory drugs do not suppress the donor's immune system.
Physical therapies such as physiotherapy and hydrotherapy are not considered treatments to suppress the condition.
Autoimmune disease can cause problems such as infertility and thrombosis (antiphospholipid or Hughes' syndrome).
Some autoimmune conditions can permanently damage the cardiovascular system. If this is known to have happened, the person should not donate as they are more likely to have a serious adverse event. |