Tissue and Cell Allograft Recipients

Xenograft recipients, recipients of biological grafts of non-human origin and bio-prosthetic grafts and organ recipients.

All donors:
Must not donate if:
a) Dura mater transplanted at any time.

b) Ocular tissue transplanted at any time.

c ) Any other allogeneic human tissue or cell transplanted since 1st January 1980.

a) If an autologous tissue, or cells, has been transplanted at any time, and there is no other reason to exclude the donor, accept.

b) If an allogeneic tissue (except dura mater or ocular tissue) or cell transplant was performed before 1st January 1980, and there is no other reason to exclude the donor, accept.

Immunosuppression
Ocular Tissue Recipient
Organ recipient
Prion Associated Diseases
Transfusion
Xenotransplantation

The transfer of tissues or cells between individuals and species has led to the spread of infection. The above guidelines are intended to minimise these risks.

People who have received a tissue or cell transplant since 1980 are excluded from donation of any tissues except for heart valves, ocular tissue, pancreatic islets and skin as a precautionary measure against the risk of transmission of vCJD in the same way as recipients of transfusion are.

Dura mater and ocular tissue allografts have been implicated in iatrogenic CJD. Iatrogenic CJD refers to the transmission of prions via inadvertent medical exposure. Recipients of dura mater and ocular tissue recipients are excluded. 

Dura mater use stopped in the UK by 1993. The situation in other countries varied so specific dates cannot be given. 

Tissue allograft recipients do not require immunosuppression. If the recipient was on immunosuppression for any other reason, see Immunosuppression entry.

This is a new entry.