Additional Information | PBSC Donors.
G-CSF may cause a flare of some autoimmune diseases. The risk should be assessed by the Designated Medical Officer and discussed with the donor.
Treatment to suppress the condition may be with steroids, immunosuppressive drugs, antimetabolites, antibodies directed against parts of the immune system as well as other therapies. These will affect the donor's immune system. This may make the donor more susceptible to certain types of infection and also will make some infections more difficult to diagnose.
Autoimmune disease is caused by the body attacking itself. This is with antibodies that are in the fluid part of the blood (plasma), and with immune cells directly attacking target cells in the part/s of the body affected.
Transfusion of antibodies, or transfer of immune cells, could lead to similar damage in the people receiving them. |