DNA-based methods must identify all HLA alleles included in the most recent WHO Nomenclature Committee for Factors of the HLA System Report2 and Nomenclature for Factors of the HLA System, 20103. Alleles should be reported either as individual alleles or as allele groups with two digits (first field). Definitions of allelic, high, intermediate and low resolution molecular HLA typing are available through EFI.
The minimum level of resolution by serological typing is given in Table 16.1. Typing to the level of broad specificities is acceptable but the higher level to include the split specificities, as indicated, is recommended. HLA-C types Cw12 and Cw14 to Cw18 have not been formally designated as recognised antigens and may not be identified serologically.
Table 16.1 HLA antigens that are defined by serological typing (with broad specificities shown in brackets)
|
HLA-A |
HLA-B |
HLA-C |
HLA-DR |
HLA-DQ |
|---|---|---|---|---|
|
A1 |
B7 |
Cw1 |
DR1 |
DQ5 (1) |
|
A2 |
B8 |
Cw2 |
DR15 (2) |
DQ6 (1) |
|
A3 |
B13 |
Cw9 (3) |
DR16 (2) |
DQ2 |
|
A11 |
B18 |
Cw10 (3) |
DR17 (3) |
DQ7 (3) |
|
A23 (A9) |
B27 |
Cw4 |
DR18 (3) |
DQ8 (3) |
|
A24 (A9) |
B35 |
Cw5 |
DR4 |
DQ9 (3) |
|
A25 (A10) |
B37 |
Cw6 |
DR11 (5) |
DQ4 |
|
A26 (A10) |
B38 (B16) |
Cw7 |
DR12 (5) |
|
|
A29 (A19) |
B39 (B16) |
Cw8 |
DR13 (6) |
|
|
A30 (A19) |
B41 |
Cw12* |
DR14 (6) |
|
|
A31 (A19) |
B42 |
Cw14* |
DR7 |
|
|
A32 (A19) |
B45 |
Cw15* |
DR8 |
|
|
A33 (A19) |
B44 |
Cw16* |
DR9 |
|
|
A34 (A10) |
B46 |
Cw17* |
DR10 |
|
|
A36 |
B47 |
Cw18* |
DR103 |
|
|
A43 |
B48 |
|
|
|
|
A66 (A10) |
B49 (B21) |
|
DR51 |
|
|
A68 (A28) |
B50 (B21) |
|
DR52 |
|
|
A69 (A28) |
B51 (B5) |
|
DR53 |
|
|
A74 (A19) |
B52 (B5) |
|
|
|
|
A80 |
B53 |
|
|
|
|
|
B54 (B22) |
|
|
|
|
|
B55 (B22) |
|
|
|
|
|
B56 (B22) |
|
|
|
|
|
B57 (B17) |
|
|
|
|
|
B58 (B17) |
|
|
|
|
|
B59 |
|
|
|
|
|
B60 (B40) |
|
|
|
|
|
B61 (B40) |
|
|
|
|
|
B62 (B15) |
|
|
|
|
|
B63 (B15) |
|
|
|
|
|
B64 (B14) |
|
|
|
|
|
B65 (B14) |
|
|
|
|
|
B67 |
|
|
|
|
|
B71 (B70) |
|
|
|
|
|
B72 (B70) |
|
|
|
|
|
B73 |
|
|
|
|
|
B75 (B15) |
|
|
|
|
|
B76 (B15) |
|
|
|
|
|
B77 (B15) |
|
|
|
|
|
B78 |
|
|
|
|
|
B81 |
|
|
|
|
|
Bw4 |
|
|
|
|
|
Bw6 |
|
|
|
|
* The products of the Cw12 and Cw14 to Cw18 genes have not been formally designated as recognised antigens and might not be identified serologically. |
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