The current nomenclature for HNA and corresponding antibodies is based on epitopes and allelic typing and this must be used for recording granulocyte-specific alloantigen and alloantibody specificities1 (see Table 17.1).
Table 17.1 Current nomenclature for HNA alleles, epitopes and corresponding antibodies
| System | Allele | Epitopes | Original name | Glycoprotein | CD |
|---|---|---|---|---|---|
|
HNA-1 |
FCGR3B*01 |
HNA-1a |
NA1 |
FcγRIIIb |
CD16 |
|
FCGR3B*02 |
HNA-1b, HNA-1d |
NA2 |
FcγRIIIb |
CD16 |
|
|
FCGR3B*03 |
HNA-1b, HNA-1c |
SH |
FcγRIIIb |
CD16 |
|
|
FCGR3B*04 |
HNA-1a |
|
FcγRIIIb |
CD16 |
|
|
FCGR3B*05 |
HNA-1bv |
|
FcγRIIIb |
CD16 |
|
|
HNA-2 |
Unknown |
HNA-2 |
NB1 |
GP56-64kDa |
CD177 |
|
HNA-3 |
SLC44A2*01 |
HNA-3a |
5b |
CTL-2 |
|
|
SLC44A2*02 |
HNA-3b |
5a |
CTL-2 |
|
|
|
SLC44A2*03 |
HNA-3av |
|
CTL-2 |
|
|
|
HNA-4 |
ITGAM*01 |
HNA-4a |
MARTa |
CD11/18 |
CD11b |
|
ITGAM*02 |
HNA-4bw |
|
CD11/18 |
CD11b |
|
|
HNA-5 |
ITGAL*01 |
HNA-5a |
ONDa |
CD11/18 |
CD11a |
|
ITGAL*01 |
HNA-5bw |
|
CD11/18 |
CD11a |
|
| v: indicates a variant epitope that may have different serological characteristics with some antisera. | |||||
| w: indicates a workshop designation – no antibodies against this epitope have currently been described. | |||||