Definition
Non-bleeding patients who receive multiple units of red cells (>10) are at risk of having excess iron stored in their body tissues leading to iron toxicity. This can damage organs such as the heart and liver.
Each unit of red cells contains about 200-250 mg of iron.
Frequency
Very Common if multiply transfused (≥1/10).
Reducing the risk
Patients on long term red cell transfusion plans should be considered for iron chelation therapy, with regular iron study tests performed.
Further information/ resources
BSH Guidelines for the monitoring and management of iron overload in patients with haemoglobinopathies and rare anaemias
NICE Iron overload treatment summary