Haemoglobin Disorders

Obligatory	Must not donate if: a) Thalassaemia major or intermedia b) Sickle cell disease (HbSS, HbSC, HbSBthal, HbSD) c) High affinity haemoglobin d) Other clinically significant structural or functional haemoglobinopathies
Discretionary	a) Donors with traits for abnormal haemoglobin, accept. Inform transplant centre b) Donors with sickle cell trait – accept for bone marrow only.
See if Relevant	Anaemia Sickle-Cell Trait Thalassaemia Trait Transfusion
Reason for Change	Stem cells from a donor who is heterozygous for a haemoglobin disorder may be accepted for transplant after a risk assessment by the transplant centre. There is no evidence of clinically significant sickling during PBSC collection in those with sickle cell trait. However, subclinical sickling has been demonstrated with PBSC collection, so those with sickle cell trait must donate by BM only.

Update Information: This entry was last updated in
TDSG-BM Edition 203, Release 29